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3740 Exposure of women to two or more early childhood stressful events, including physical, emotional, or sexual abuse, is positively correlated with an increased risk of Th1, Th2, and rheumatic autoimmune development later in life compared with women reporting no events in childhood (p 900 mcg/m 3 when indoor cooking stoves are used)

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Alterations in Rac1 activity were also affected by several autism-risk gene mutations, including fragile X mental retardation 1 (Fmr1), neurexin 1 (Nrx1), neuroligin 4 (Nlg4), and tuberous sclerosis 1 (Tsc1)

This imbalance is believed to be manifested in most brain regions, including the amygdala, cortex, and hippocampus, and plays a central role in several pathological conditions, such as Fragile X Syndrome (FXS), epilepsy, and ASD